On the anomalous behaviour on gel-filtration and SDS-electrophoresis of prothymosin-alpha.
- Published Article
- Publication Date
Dec 01, 1992
The regulator of T-cell proliferation prothymosin alpha, is a protein with a relative molecular mass of 12 KDa as calculated from its amino acid sequence. This immunoregulator exhibits anomalous behaviour on gel-filtration and SDS-PAGE electrophoresis appearing as oligomers which are 5 or 2 fold larger than the corresponding polypeptide. These results suggest that a dimeric form of prothymosin alpha is stable to dissociation by SDS and reduction by beta-mercapto ethanol.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/1290467