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Annexin A5 uptake in ischemic myocardium: demonstration of reversible phosphatidylserine externalization and feasibility of radionuclide imaging.

Authors
  • Kenis, Heidi
  • Zandbergen, Harmen Reinier
  • Hofstra, Leonard
  • Petrov, Artiom D
  • Dumont, Ewald A
  • Blankenberg, Francis D
  • Haider, Nezam
  • Bitsch, Nicole
  • Gijbels, Marion
  • Verjans, Johan W H
  • Narula, Navneet
  • Narula, Jagat
  • Reutelingsperger, Chris P M
Type
Published Article
Publication Date
Feb 01, 2010
Volume
51
Issue
2
Pages
259–267
Identifiers
DOI: 10.2967/jnumed.109.068429
PMID: 20124049
Source
Medline
License
Unknown

Abstract

After a single episode of ischemia, cardiomyocytes express phosphatidylserine, which is amenable to targeting by AA5, for at least 6 h. Phosphatidylserine exposure is transient and internalized in cytoplasmic vesicles after AA5 binding, indicating the reversibility of the apoptotic process.

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