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Animal models of tumor immunity, immunotherapy and cancer vaccines.

Authors
  • Ostrand-Rosenberg, Suzanne
Type
Published Article
Journal
Current Opinion in Immunology
Publisher
Elsevier
Publication Date
Apr 01, 2004
Volume
16
Issue
2
Pages
143–150
Identifiers
PMID: 15023405
Source
Medline
License
Unknown

Abstract

Reliable animal models are critical for evaluating immunotherapies and for defining tumor immunology paradigms. Tumor immunologists are moving away from traditional transplantation tumor systems because they do not adequately model human malignancies. Transgenic mouse models in which tumors arise spontaneously have been developed for most cancers. The models use one of three technologies: tissue-specific promoters to drive expression of SV40 large T antigen or tissue-specific oncogenes; deletion of tumor suppressor genes by gene targeting; or, conditional deletion of tumor suppressor genes or activation of oncogenes via Cre-lox technology. Knockin mice expressing human tumor antigens and gene-targeted mice with deletions for immunologically relevant molecules have been integral to advancing knowledge of the tumor-host relationship. Although animal models are becoming more sophisticated, additional improvements are needed so that more realistic models can be developed.

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