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Angiotensin II type 1 receptor activation increases microvascular hydraulic permeability.

Authors
  • Newton, Christopher R1
  • Curran, Brian
  • Victorino, Gregory P
  • 1 Department of Surgery, University of California at San Francisco-East Bay, Alameda County Medical Center, Oakland, CA 94602, USA.
Type
Published Article
Journal
Surgery
Publisher
Elsevier
Publication Date
November 2004
Volume
136
Issue
5
Pages
1054–1060
Identifiers
PMID: 15523401
Source
Medline
License
Unknown

Abstract

We conclude that endothelial cell Ang II receptors play an important role in modulating transendothelial fluid flux. Activating the AT1 receptor increases L(p); the AT2 receptor may operate to oppose this action. Pharmacologic manipulation of Ang II receptors may be beneficial during shock states to limit intravascular fluid loss.

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