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The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.

Authors
  • Fendrich, Volker
  • Chen, Nai-Ming
  • Neef, Meike
  • Waldmann, Jens
  • Buchholz, Malte
  • Feldmann, Georg
  • Slater, Emily P
  • Maitra, Anirban
  • Bartsch, Detlef K
Type
Published Article
Journal
Gut
Publisher
BMJ
Publication Date
May 01, 2010
Volume
59
Issue
5
Pages
630–637
Identifiers
DOI: 10.1136/gut.2009.188961
PMID: 19880966
Source
Medline
License
Unknown

Abstract

Using a transgenic mouse model that imitates human pancreatic cancer, this study provides first evidence that aspirin and enalapril are effective chemopreventive agents by delaying the progression of PanINs and partially inhibiting the formation of murine pancreatic cancer. This study together supports the hypothesis that aspirin and ACE inhibitors might be a valid chemopreventive strategy.

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