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Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.

Authors
  • Lam, Ho Yin Pekkle1
  • Chen, Tina Tu-Wen2
  • Chen, Cheng-Chi3
  • Yang, Ting-Hua4
  • Cheng, Po-Ching5
  • Peng, Shih-Yi6
  • 1 Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien 97004, Taiwan. , (Taiwan)
  • 2 Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan. , (Taiwan)
  • 3 Department of Laboratory Medicine, Taipei Medical University-Shuang-Ho Hospital, New Taipei City 23561, Taiwan. , (Taiwan)
  • 4 Institute of Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien 97004, Taiwan. , (Taiwan)
  • 5 Department of Molecular Parasitology and Tropical Diseases, School of Medicine, Taipei Medical University, Taipei 110, Taiwan; Research Center of International Tropical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. , (Taiwan)
  • 6 Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien 97004, Taiwan. Electronic address: [email protected] , (Taiwan)
Type
Published Article
Journal
Parasitology international
Publication Date
Aug 01, 2020
Volume
77
Pages
102119–102119
Identifiers
DOI: 10.1016/j.parint.2020.102119
PMID: 32283319
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Angiostrongylus cantonensis is a metastrongyloid nematode that causes eosinophilic meningoencephalitis in humans. A high infestation of A. cantonensis can cause permanent brain damage or even death. The inflammasome is an oligomeric molecular platform that can detect microbial pathogens and activate inflammatory cytokines. The recognition of larval surface antigens by pattern recognition receptors (PRRs) can cause oligomerization of the NOD-like receptor (NLR) or absent in melanoma 2 (AIM2) with the adaptor apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) to form a caspase-1-activating scaffold. Activated caspase-1 converts pro-inflammatory cytokines into their mature, active forms. Helminths infection has been shown to activate NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasomes. In this study, we aimed to investigate the mechanism of inflammasome activation upon A. cantonensis infection in a mouse model. This study provides evidence that A. cantonensis infection can activate NLRP1B and NLRC4 inflammasomes and promote pyroptosis to cause meningoencephalitis. Copyright © 2020 Elsevier B.V. All rights reserved.

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