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Anemia and potassium permeability of red blood cells in analbuminemic rats.

Authors
  • Sugiyama, K
  • Emori, T
  • Shumiya, S
  • Nagase, S
Type
Published Article
Journal
Jikken dobutsu. Experimental animals
Publication Date
Jul 01, 1984
Volume
33
Issue
3
Pages
307–318
Identifiers
PMID: 6542021
Source
Medline
License
Unknown

Abstract

A mutant strain, Nagase analbuminemia rats (NAR), was established from Sprague-Dawley rats. Hematological evaluations were made on NAR of 4 to 52 weeks of age. NAR had an abnormally low number of red blood cells (RBC), a low hematocrit, a reduced hemoglobin concentration and an increased number of reticulocytes. Their plasma electrolyte level was normal. Osmotic fragility of RBC was slightly increased in the rats. Thus NAR shows a slight anemia. The in vitro experiments on RBC were performed. The incubation of blood showed a hemolytic tendency and elevated potassium efflux in the blood of NAR. In addition, an increased efflux of potassium was found in the RBC of NAR, when the RBC was washed with phosphate buffered saline and then was incubated with the saline containing CaCl2. This potassium efflux was prevented in the presence of rat albumin. These findings suggest that the deficiency of serum albumin may increase the permeability of potassium in erythrocyte membrane in NAR.

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