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Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia.

Authors
Type
Published Article
Journal
Journal of Medical Genetics
1468-6244
Publisher
BMJ
Publication Date
Volume
43
Issue
2
Pages
187–192
Identifiers
PMID: 15908568
Source
Medline

Abstract

Preferential allocation of the normal cells into the trophoblast explains the absence of trophoblast overgrowth, a key feature of this syndrome. Interestingly, the distribution of androgenetic cells appears to differ from that reported for artificially created androgenetic mouse chimeras. Androgenetic mosaicism for the first time provides an aetiology for PMD, and may be a novel mechanism for BWS and unexplained intrauterine growth restriction.

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