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Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia.

Authors
  • Kaiser-Rogers, K A
  • McFadden, D E
  • Livasy, C A
  • Dansereau, J
  • Jiang, R
  • Knops, J F
  • Lefebvre, L
  • Rao, K W
  • Robinson, W P
Type
Published Article
Journal
Journal of Medical Genetics
Publisher
BMJ
Publication Date
Feb 01, 2006
Volume
43
Issue
2
Pages
187–192
Identifiers
PMID: 15908568
Source
Medline
License
Unknown

Abstract

Preferential allocation of the normal cells into the trophoblast explains the absence of trophoblast overgrowth, a key feature of this syndrome. Interestingly, the distribution of androgenetic cells appears to differ from that reported for artificially created androgenetic mouse chimeras. Androgenetic mosaicism for the first time provides an aetiology for PMD, and may be a novel mechanism for BWS and unexplained intrauterine growth restriction.

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