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Anatomical correlates of early mutism in progressive nonfluent aphasia.

Authors
  • Gorno-Tempini, M L
  • Ogar, J M
  • Brambati, S M
  • Wang, P
  • Jeong, J H
  • Rankin, K P
  • Dronkers, N F
  • Miller, B L
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Nov 28, 2006
Volume
67
Issue
10
Pages
1849–1851
Identifiers
PMID: 16931509
Source
Medline
License
Unknown

Abstract

Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease. Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy. In PNFA with early mutism, volume loss was more prominent in the pars opercularis and extended into the left basal ganglia. Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA.

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