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[Analysis of the stability of some properties of tick-borne encephalitis virus (strain 205) upon passaging in mice].

Authors
  • Karpova, M R
  • Vorob'eva, M S
  • Kushch, A A
  • Kiseleva, N N
  • Rasshchepkina, M N
  • Ladyzhenskaia, I P
  • Mel'nikova, E E
  • Shpilevaia, M V
  • Amanadze, S N
  • Vorovich, M F
Type
Published Article
Journal
Voprosy virusologii
Publication Date
Jan 01, 1995
Volume
40
Issue
5
Pages
205–208
Identifiers
PMID: 8659173
Source
Medline
License
Unknown

Abstract

Comparative analysis of the characteristics of tick-borne encephalitis (TBE) strain 205 used for the production of vaccine against TBE and of its variants obtained by passages in mouse brain showed the stability of such properties as infective activity, neurovirulence, sensitivity to physical (heating to 50 C) and chemical (sodium deoxycholate treatment) factors. At the same time increased neurovirulence of variants 205/M10 and 205/M20, which undergone through 10 and 20 passages in white mouse brain, for low-sensitive Syrian hamsters was revealed. Use of a panel of 5 monoclonal antibodies to protein E and of 4 monoclonal antibodies to protein E and of 4 monoclonal antibodies to protein NS3 helped differentiate between not only strains 205 and Sofyin, but between variants of strain 205 as well.

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