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An analysis of naltrexone and naloxone's possible agonistic actions in the dog.

Authors
Type
Published Article
Journal
Drug and Alcohol Dependence
0376-8716
Publisher
Elsevier
Publication Date
Volume
15
Issue
4
Pages
353–360
Identifiers
PMID: 2865117
Source
Medline

Abstract

Naltrexone (0.01-2.0 mg/kg, i.v.) produced dose-dependent EEG slowing in the conscious dog as did morphine (0.5-8 mg/kg, i.v.) and fentanyl (5-20 micrograms/kg, i.v.). However, the dose-response curve for naltrexone was not parallel to the morphine or fentanyl dose-response curves. Morphine and fentanyl but not naltrexone also produced dose-dependent miosis and increased the skin twitch reflex latency. When administered into the fourth cerebral ventricle naltrexone (60 micrograms), morphine (80 micrograms) and ethylketazocine (30 micrograms) produced EEG slowing. Again, naltrexone did not alter the skin twitch latency whereas morphine lengthened it and ethylketazocine reduced it. The pharmacological profiles obtained from different routes of administration indicate that naltrexone is clearly different from morphine, fentanyl and ethylketazocine. However, naltrexone may act as a partial agonist in the production of EEG slowing at a previously unidentified opioid receptor.

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