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Analysis of GM-CSF gene polymorphisms (3606T/C and 3928C/T) in Japanese patients with atopic dermatitis.

Authors
  • Saeki, H
  • Tsunemi, Y
  • Asano, N
  • Nakamura, K
  • Sekiya, T
  • Hirai, K
  • Kakinuma, T
  • Fujita, H
  • Kagami, S
  • Tamaki, K
Type
Published Article
Journal
Clinical and experimental dermatology
Publication Date
Mar 01, 2006
Volume
31
Issue
2
Pages
278–280
Identifiers
PMID: 16487109
Source
Medline
License
Unknown

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is thought to play an important role in the pathogenesis of atopic dermatitis. To examine whether GM-CSF single nucleotide polymorphisms (SNPs) are associated with susceptibility to atopic dermatitis, we investigated the genotype and allele frequencies of the SNPs 3606T/C and 3928C/T of the GM-CSF gene in 181 Japanese patients with atopic dermatitis and 100 controls, using a PCR restriction fragment length polymorphism method. A strong linkage disequilibrium existed between the polymorphisms 3606 and 3928, suggesting two common GM-CSF haplotypes, 3606*T-3928*C and 3606*C-3928*T. However, there was no significant difference in genotype or allele frequencies between patients with atopic dermatitis and controls for either of the two polymorphisms, thus GM-CSF SNPs do not appear to be associated with susceptibility to atopic dermatitis in Japanese patients. A large-scale study is necessary to confirm these findings.

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