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Analysis of gene expression in wild-type and Notch1 mutant retinal cells by single cell profiling.

Authors
  • Mizeracka, Karolina
  • Trimarchi, Jeffrey M
  • Stadler, Michael B
  • Cepko, Constance L
Type
Published Article
Journal
Developmental Dynamics
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 01, 2013
Volume
242
Issue
10
Pages
1147–1159
Identifiers
DOI: 10.1002/dvdy.24006
PMID: 23813500
Source
Medline
Keywords
License
Unknown

Abstract

The majority of Notch1-mutant cells lost expression of known Notch target genes. These cells also had low levels of RPC and cell cycle genes, and robustly up-regulated rod precursor genes. In addition, single wild-type cells, in which cell cycle marker genes were down-regulated, expressed markers of both rod photoreceptors and interneurons.

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