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Analysis of in-field control and late toxicity for adults with early-stage Hodgkin's disease treated with chemotherapy followed by radiotherapy.

Authors
  • Chronowski, Gregory M
  • Wilder, Richard B
  • Tucker, Susan L
  • Ha, Chul S
  • Younes, Anas
  • Fayad, Luis
  • Rodriguez, Maria A
  • Hagemeister, Fredrick B
  • Barista, Ibrahim
  • Cabanillas, Fernando
  • Cox, James D
Type
Published Article
Journal
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier
Publication Date
Jan 01, 2003
Volume
55
Issue
1
Pages
36–43
Identifiers
PMID: 12504034
Source
Medline
License
Unknown

Abstract

In patients with nonbulky disease, induction chemotherapy followed by RT to a median dose of 40.0 Gy resulted in excellent IF control, regardless of the chemotherapeutic regimen used, the fact that only 1-2 cycles of chemotherapy were delivered, and the response to chemotherapy. There was a trend toward a higher incidence of solid tumors in patients who received consolidation RT to both sides rather than only one side of the diaphragm. Ongoing Phase III trials will help clarify whether lower RT doses and smaller RT fields after chemotherapy can maintain the IF control seen in our study, but with a lower incidence of late complications in patients with Stage I or II Hodgkin's disease.

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