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Analysis of effect of two concurrent ischaemic zones on left ventricular function.

Authors
Type
Published Article
Journal
Medical & biological engineering & computing
Publication Date
Volume
34
Issue
6
Pages
477–480
Identifiers
PMID: 9039752
Source
Medline
License
Unknown

Abstract

Left ventricular (LV) function due to two concurrent ischaemic zones (IZs) is investigated using a cardiovascular system model. The model comprises a three-compartment LV, the venous return and the arterial system. Haemodynamic responses of the LV to changes in the IZ size and myocardial contraction timings are explored. Results show that the greater the degree of asynschonisation is between the normal zone and the IZ, and the larger the ischaemic size, the more severe the LV dysfunction. Pre-load augmentation improves LV function. Model-predicted features are consistent with reported observations associated with myocardial ischaemia. The extent of the usefulness and limitations of this model is also discussed.

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