This paper concerns with detailed analysis of a reaction-diffusion host-pathogen model with space-dependent parameters in a bounded domain. By considering the fact the mobility of host individuals playing a crucial role in disease transmission, we formulate the model by a system of degenerate reaction-diffusion equations, where host individuals disperse at distinct rates and the mobility of pathogen is ignored in the environment.We first establish the well-posedness of the model, including the global existence of solution and the existence of the global compact attractor. The basic reproduction number is identified, and also characterized by some equivalent principal spectral conditions, which establishes the threshold dynamical result for pathogen extinction and persistence. When the positive steady state is confirmed, we investigate the asymptotic profiles of positive steady state as host individuals disperse at small and large rates. Our result suggests that small and large diffusion rate of hosts have a great impacts in formulating the spatial distribution of the pathogen.