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Analysis of the Cys82Arg mutation in follicle-stimulating hormone beta (FSHbeta) using a novel FSH expression vector.

Authors
  • Clark, Andrew D
  • Layman, Lawrence C
Type
Published Article
Journal
Fertility and Sterility
Publisher
Elsevier
Publication Date
Feb 01, 2003
Volume
79
Issue
2
Pages
379–385
Identifiers
PMID: 12568849
Source
Medline
License
Unknown

Abstract

The Cys82Arg mutation in a male with normal puberty and azoospermia results in profound deficiency of FSH in vitro, thereby confirming the molecular basis of hypogonadism in this patient and documenting the importance of the Cys residue at position 82 of the FSHbeta subunit.

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