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[Analysis of chemical constituents from Citrus aurantium by UHPLC-LTQ-Orbitrap-MS/MS].

Authors
  • Yu, Guo-Hua1, 2
  • Yang, Hong-Jun2
  • Li, Jun-Fang2, 3
  • Geng, Ya2, 4
  • Dong, Ling1
  • Xu, Hai-Yu2
  • 1 School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. , (China)
  • 2 Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. , (China)
  • 3 School of Chinese Materia Medica, Tianjin University of Chinese Medicine, Tianjin 300193, China. , (China)
  • 4 School of Basic Medicine, Shandong University of Chinese Medicine, Jinan 250355, China. , (China)
Type
Published Article
Journal
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Publication Date
Sep 01, 2016
Volume
41
Issue
18
Pages
3371–3378
Identifiers
DOI: 10.4268/cjcmm20161811
PMID: 28925120
Source
Medline
Keywords
Language
Chinese
License
Unknown

Abstract

In this study, a ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap-MS/MS) method was developed to analyze the chemical components in Citrus aurantium. C. aurantium were extracted with 75% methanol, and we applied a Thermo Scientific BDS Hypersil C₁₈ column (2.1 mm×150 mm, 2.4 μm) to UHPLC analysis with acetonitrile-water (containing 0.1% formic acid) in gradient as mobile phase. Elutes were then detected by ESI-LTQ-Orbitrap-MS/MS. A total of 27 components were identified, including fourteen flavonoids, seven coumarins, five limonoids and one alkaloid. This study showed an insight into the composition of C. aurantium, which could provide theoretical foundation for further study and utilization of the medicinal resources. Copyright© by the Chinese Pharmaceutical Association.

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