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[Analysis of the bone anabolic agent by intravital imaging technique.]

Authors
  • Morimoto, Akito1
  • Kikuta, Junichi1
  • Furuya, Masayuki1
  • Ishii, Masaru1
  • 1 Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan. , (Japan)
Type
Published Article
Journal
Clinical calcium
Publication Date
Jan 01, 2018
Volume
28
Issue
2
Pages
243–248
Identifiers
DOI: CliCa1802243248
PMID: 29371491
Source
Medline
License
Unknown

Abstract

Teriparatide, recombinant human PTH(1-34), is the only anabolic agent widely used for osteoporosis. This drug is thought to promote bone formation by modulating bone remodeling system, although the detailed mechanism remains unclear. Recently, we developed a novel intravital imaging technique to visualize mature osteoclasts and mature osteoblasts simultaneously. By means of this system, we revealed the effect of teriparatide on three-dimensional distribution and cell-to-cell interactions between these cells. Advances in these imaging studies may lead to further understanding of the intercellular network in bone metabolism.

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