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Analyses by GC-MS and GC-MS-MS of the Hantzsch synthesis products using hydroxy- and methoxy-aromatic aldehydes.

Authors
  • Núñez-Vergara, Luis J1
  • Navarrete-Encina, P A
  • Salas, S
  • Conde, B
  • Carbajo, J
  • Squella, J A
  • Camargo, C
Type
Published Article
Journal
Journal of Pharmaceutical and Biomedical Analysis
Publisher
Elsevier
Publication Date
May 09, 2007
Volume
44
Issue
1
Pages
236–242
Identifiers
PMID: 17367976
Source
Medline
License
Unknown

Abstract

EI mass spectra of products of the dihydropyridine Hantzsch synthesis using hydroxy and methoxy aldehydes as starting materials are reported. The reaction products (C-4 hydroxy- and methoxyphenyl-1,4-dihydropyridines and chromeno[3,4,c]-pyridines) were derivatized with N-methyl-N-(trimethylsilyl)-trifluoracetamide to be analyzed by gas chromatographic techniques. Fragmentation pathways for 1,4-dihydropyridines and chromeno-pyridines are proposed. The study provides (mainly through MS-MS technique) useful data for the confirmation of the structure of the compounds and also is a valuable tool for further analytical purposes to follow both photostability and reactivity studies with free radicals for these types of compounds.

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