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An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues

Authors
  • Said AS Ghozlan
  • Khadija O Badahdah
  • Ismail A Abdelhamid
Publisher
BioMed Central
Publication Date
May 01, 2007
Source
PMC
Keywords
License
Unknown

Abstract

3-Oxo-2-arylhydrazononitriles 1a-c react readily with chloroacetonitrile, ethyl chloroacetate, and with phenacyl chloride to give 4-aminopyrazoles 4a-e. The pyrazolo[4,3-d]pyrimidine derivatives 7 and 10 are synthesized via reaction of the aminopyrazole 4b with phenylisothiocyanate and DMFDMA/NH4OAc respectively.

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