Affordable Access

deepdyve-link
Publisher Website

Amyotrophic Lateral Sclerosis and its Mimics/Variants: A Comprehensive Review.

Authors
  • Yedavalli, Vivek S1
  • Patil, Abhijit2
  • Shah, Parinda2
  • 1 Department of Neuroradiology and Neurointervention, Stanford University, Palo Alto, California, USA.
  • 2 Department of Radiology, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA.
Type
Published Article
Journal
Journal of clinical imaging science
Publication Date
Jan 01, 2018
Volume
8
Pages
53–53
Identifiers
DOI: 10.4103/jcis.JCIS_40_18
PMID: 30652056
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Motor neuron diseases (MNDs) are a debilitating subset of diseases, which result in progressive neuronal destruction and eventual loss of voluntary muscular function. These entities are often challenging to distinguish and accurately diagnose given overlapping clinical pictures and overall rarity. This group of diseases has a high morbidity and mortality rate overall and delineating each type of disease can help guide appropriate clinical management and improve quality of life for patients. Of all MNDs, amyotrophic lateral sclerosis (ALS) is by far the most common comprising 80%-90% of cases. However, other mimics and variants of ALS can appear similar both clinically and radiographically. In this review, we delve into the epidemiological, physiological, neuroimaging, and prognostic characteristics and management of ALS and its most common MND mimics/variants. In doing so, we hope to improve accuracy in diagnosis and potential management for this rare group of diseases.

Report this publication

Statistics

Seen <100 times