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Amyotrophic lateral sclerosis - cell based therapy and novel therapeutic development.

Authors
  • Kim, Changsung
  • Lee, Hee Chul
  • Sung, Jung-Joon
Type
Published Article
Journal
Experimental neurobiology
Publication Date
Sep 01, 2014
Volume
23
Issue
3
Pages
207–214
Identifiers
DOI: 10.5607/en.2014.23.3.207
PMID: 25258567
Source
Medline
Keywords
License
Unknown

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized by the predominant loss of motor neurons (MNs) in primary motor cortex, the brainstem, and the spinal cord, causing premature death in most cases. Minimal delay of pathological development by available medicine has prompted the search for novel therapeutic treatments to cure ALS. Cell-based therapy has been proposed as an ultimate source for regeneration of MNs. Recent completion of non-autologous fetal spinal stem cell transplant to ALS patients brought renewed hope for further human trials to cure the disease. Autologous somatic stem cell-based human trials are now in track to reveal the outcome of the ongoing trials. Furthermore, induced pluripotent stem cell (iPSC)-based ALS disease drug screen and autologous cell transplant options will broaden therapeutic options. In this review paper, we discuss recent accomplishments in cell transplant treatment for ALS and future options with iPSC technology.

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