Affordable Access

Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat.

Authors
  • Clementi, G
  • Caruso, A
  • Cutuli, V M
  • de Bernardis, E
  • Prato, A
  • Amico-Roxas, M
Type
Published Article
Journal
Experientia
Publication Date
Jul 15, 1996
Volume
52
Issue
7
Pages
677–679
Identifiers
PMID: 8698109
Source
Medline
License
Unknown

Abstract

The effect of rat amylin on gastric emptying and intestinal transit in the rat was examined. Amylin administered intracerebroventricularly (1, 2, 2.5 or 4 micrograms/rat) produced the maximal decrease in gastric emptying and intestinal transit at the dose of 2.5 micrograms/rat. Higher doses produced a lower effect. Peripheral administration (25, 50 or 100 micrograms/kg) produced dose-dependent effects. Pre-treatment with neostigmine blocked the effect of amylin when it was centrally injected, while the effect of amylin given peripherally was partially reduced. Pre-treatment with domperidone decreased the inhibitory effect of peripherally injected amylin, but no effect was observed when the peptide was centrally injected.

Report this publication

Statistics

Seen <100 times