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Amygdaloid changes in aging and dementia.

Authors
  • Herzog, A G
  • Kemper, T L
Type
Published Article
Journal
Archives of Neurology
Publisher
American Medical Association
Publication Date
Oct 01, 1980
Volume
37
Issue
10
Pages
625–629
Identifiers
PMID: 7425886
Source
Medline
License
Unknown

Abstract

A quantitative and clincally correlated investigation was carried out to determine the divisional distribution of volumetric and cell-packing density changes in the amygdala in patients with advanced aging and senile dementia. Normal controls show relatively little, but nevertheless significant, age-related change. In contrast, the amygdala undergoes very marked degeneration in patients with senile dementia, which preferentially affects the morphologcially, developmentally, and connectionally older medial, medial central, and cortical nuclei. These findings strengthen the possibility that the amygdala participates in the behavioral changes that occur in senile dementia.

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