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AMR-Intervene: a social-ecological framework to capture the diversity of actions to tackle antimicrobial resistance from a One Health perspective.

  • Léger, Anaïs1
  • Lambraki, Irene2
  • Graells, Tiscar3, 4
  • Cousins, Melanie2
  • Henriksson, Patrik J G4, 5, 6
  • Harbarth, Stephan7
  • Carson, Carolee8
  • Majowicz, Shannon2
  • Troell, Max4, 5
  • Parmley, E Jane9
  • Jørgensen, Peter S3, 4
  • Wernli, Didier1
  • 1 Global Studies Institute, University of Geneva, Sciences II, Quai Ernest-Ansermet 30, CH -1211 Genève 4, Switzerland. , (Switzerland)
  • 2 School of Public Health and Health Systems, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada. , (Canada)
  • 3 Global Economic Dynamics and the Biosphere, The Royal Swedish Academy of Sciences, Box 50005, 104 05 Stockholm, Sweden. , (Sweden)
  • 4 Stockholm Resilience Centre, Stockholm University, Kräftriket 2B, 10691 Stockholm, Sweden. , (Sweden)
  • 5 Beijer Institute of Ecological Economics, The Royal Swedish Academy of Sciences, PO Box 50005, SE-104 05 Stockholm, Sweden. , (Sweden)
  • 6 WorldFish, Jalan Batu Maung, 11960 Bayan Lepas, Penang, Malaysia. , (Malaysia)
  • 7 Infection Control Program and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland. , (Switzerland)
  • 8 Canadian Integrated Program for Antimicrobial Resistance Surveillance; Public Health Agency of Canada, Guelph, Canada. , (Canada)
  • 9 Department of Population Medicine, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada. , (Canada)
Published Article
Journal of Antimicrobial Chemotherapy
Oxford University Press
Publication Date
Oct 14, 2020
DOI: 10.1093/jac/dkaa394
PMID: 33057678


The global threat of antimicrobial resistance (AMR) requires coordinated actions by and across different sectors. Increasing attention at the global and national levels has led to different strategies to tackle the challenge. The diversity of possible actions to address AMR is currently not well understood from a One Health perspective. AMR-Intervene, an interdisciplinary social-ecological framework, describes interventions to tackle AMR in terms of six components: (i) core information about the publication; (ii) social system; (iii) bio-ecological system; (iv) triggers and goals; (v) implementation and governance; and (vi) assessment. AMR-Intervene provides a broadly applicable framework, which can inform the design, implementation, assessment and reporting of interventions to tackle AMR and, in turn, enable faster uptake of successful interventions to build societal resilience to AMR. © The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: [email protected]

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