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AMPK and p53 help cells through lean times.

Authors
  • Thoreen, Carson C
  • Sabatini, David M
Type
Published Article
Journal
Cell Metabolism
Publisher
Elsevier
Publication Date
May 01, 2005
Volume
1
Issue
5
Pages
287–288
Identifiers
PMID: 16054073
Source
Medline
License
Unknown

Abstract

Cells that encounter low nutrient conditions often respond by arresting cell division or becoming apoptotic. Recent work by Jones and colleagues (Jones et al.,2005) reveals how the AMP-activated kinase mediates this process by phosphorylating and activating the tumor suppressor p53.

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