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AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience

Authors
  • Campelo, Tiago1
  • Augusto, Elisabete1
  • Chenouard, Nicolas1
  • de Miranda, Aron1
  • Kouskoff, Vladimir1
  • Camus, Come1
  • Choquet, Daniel1, 2
  • Gambino, Frédéric1
  • 1 University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, 33000 Bordeaux, France
  • 2 University of Bordeaux, CNRS, INSERM, Bordeaux Imaging Center, BIC, UMS 3420, US 4, 33000 Bordeaux, France
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Sep 01, 2020
Volume
32
Issue
9
Identifiers
DOI: 10.1016/j.celrep.2020.108097
PMID: 32877679
PMCID: PMC7487777
Source
PubMed Central
Keywords
License
Unknown

Abstract

By manipulating surface AMPARs in vivo , Campelo et al. study the function of synaptic potentiation in the whisker-to-cortex system of mice upon whisker trimming. They reveal that the remapping of somatosensory regions and the recovery of altered skills depend on the potentiation of glutamatergic synapses onto layer 2/3 pyramidal neurons.

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