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AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation

Authors
  • Peter, Saša1
  • Urbanus, Bastiaan H.A.1
  • Klaassen, Remco V.2
  • Wu, Bin1, 3
  • Boele, Henk-Jan1
  • Azizi, Sameha1
  • Slotman, Johan A.4
  • Houtsmuller, Adriaan B.4
  • Schonewille, Martijn1
  • Hoebeek, Freek E.1, 5
  • Spijker, Sabine2
  • Smit, August B.2
  • De Zeeuw, Chris I.1, 6
  • 1 Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, the Netherlands
  • 2 Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, 1081 HV Amsterdam, the Netherlands
  • 3 Department of Neurology, Huashan Hospital, Fudan University, 200040 Shanghai, China
  • 4 Optical Imaging Centre, Department of Pathology, Erasmus MC, 3000 DR Rotterdam, the Netherlands
  • 5 Department for Developmental Origins of Disease, Wilhelmina Children’s Hospital, Brain Center, UMC Utrecht, 3584 EA Utrecht, the Netherlands
  • 6 Netherlands Institute for Neuroscience, 1105 CA Amsterdam, the Netherlands
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Aug 01, 2013
Volume
31
Issue
2
Identifiers
DOI: 10.1016/j.celrep.2020.03.079
PMID: 32294428
PMCID: PMC7175376
Source
PubMed Central
Keywords
License
Unknown

Abstract

Peter et al. show that the SHISA6 protein modulates the synaptic function of Purkinje cells in mice. In the absence of SHISA6, memory formation during classical eyeblink conditioning and eye movement adaptations is severely impaired as a result of a major synaptic excitability phenotype in Purkinje cells.

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