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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

Authors
  • Kahn, Barbara B
  • Alquier, Thierry
  • Carling, David
  • Hardie, D Grahame
Type
Published Article
Journal
Cell Metabolism
Publisher
Elsevier
Publication Date
Jan 01, 2005
Volume
1
Issue
1
Pages
15–25
Identifiers
PMID: 16054041
Source
Medline
License
Unknown

Abstract

The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy status, and recent data demonstrate that it also plays a critical role in systemic energy balance. AMPK integrates nutritional and hormonal signals in peripheral tissues and the hypothalamus. It mediates effects of adipokines (leptin, adiponectin, and possibly resistin) in regulating food intake, body weight, and glucose and lipid homeostasis. AMPK is regulated by upstream kinases of which the tumor suppressor, LKB1, is the first to be identified. Complex signaling networks suggest that AMPK may prevent insulin resistance, in part by inhibiting pathways that antagonize insulin signaling. Through signaling, metabolic, and gene expression effects, AMPK enhances insulin sensitivity and fosters a metabolic milieu that may reduce the risk for obesity and type 2 diabetes.

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