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Amitriptyline suppresses neuroinflammation-dependent interleukin-10-p38 mitogen-activated protein kinase-heme oxygenase-1 signaling pathway in chronic morphine-infused rats.

Authors
  • Tai, Yueh-Hua
  • Tsai, Ru-Yin
  • Lin, Shinn-Long
  • Yeh, Chun-Chang
  • Wang, Jhi-Joung
  • Tao, Pao-Luh
  • Wong, Chih-Shung
Type
Published Article
Journal
Anesthesiology
Publication Date
Jun 01, 2009
Volume
110
Issue
6
Pages
1379–1389
Identifiers
DOI: 10.1097/ALN.0b013e31819fccd5
PMID: 19417613
Source
Medline
License
Unknown

Abstract

These results suggest that the antiinflammatory effect of amitriptyline on morphine tolerance, probably acting by increasing IL-10 expression, is mediated by p38 mitogen-activated protein kinase heme oxygenase-1 signal transduction cascade.

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