Affordable Access

Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists.

Authors
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
15
Issue
23
Pages
5293–5297
Identifiers
PMID: 16203136
Source
Medline
License
Unknown

Abstract

The synthesis and biological evaluation of novel 3-amino indazole melanin concentrating hormone receptor-1 antagonists are reported, several of which demonstrated functional activity of less than 100nM. Compounds 19 and 28, two of the more potent compounds identified in this study, were characterized by high exposure in the brain and demonstrated robust efficacy when dosed in diet-induced obese mice.

Statistics

Seen <100 times