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Aminoheterocycles as synthons for combinatorial Biginelli reactions.

Authors
  • Ryabukhin, Sergey V
  • Plaskon, Andrey S
  • Boron, Sergey Yu
  • Volochnyuk, Dmitriy M
  • Tolmachev, Andrey A
Type
Published Article
Journal
Molecular Diversity
Publisher
Springer-Verlag
Publication Date
Feb 01, 2011
Volume
15
Issue
1
Pages
189–195
Identifiers
DOI: 10.1007/s11030-010-9253-6
PMID: 20449767
Source
Medline
License
Unknown

Abstract

Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the synthesis of diverse dihydropyrimidines via Biginelli type MCR-heterocyclization using aminoheterocycles. High yields and a simple workup of target compounds enable the facile generation of combinatorial libraries comprising more than 2,000 compounds of high structural and functional diversity. A representative set of 89 compounds is described.

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