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Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells.

Authors
Type
Published Article
Journal
Journal of medicinal chemistry
Publication Date
Volume
49
Issue
8
Pages
2652–2655
Identifiers
PMID: 16610808
Source
Medline

Abstract

Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives.

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