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Amiloride attenuates lipopolysaccharide-accelerated atherosclerosis via inhibition of NHE1-dependent endothelial cell apoptosis.

Authors
Type
Published Article
Journal
Acta pharmacologica Sinica
Publication Date
Volume
34
Issue
2
Pages
231–238
Identifiers
DOI: 10.1038/aps.2012.155
PMID: 23274414
Source
Medline

Abstract

LPS stimulates NHE1 activity, increases [Ca(2+)](i), and activates calpain, which leads to endothelial cell apoptosis related to decreased Bcl-2 expression. Amiloride inhibits NHE1 activity, thus attenuates LPS-accelerated atherosclerosis in mice.

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