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Amiloride attenuates lipopolysaccharide-accelerated atherosclerosis via inhibition of NHE1-dependent endothelial cell apoptosis.

Authors
  • Cui, Gui-mei1
  • Zhao, Yu-xi
  • Zhang, Na-na
  • Liu, Zeng-shan
  • Sun, Wan-chun
  • Peng, Qi-sheng
  • 1 Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun, China. , (China)
Type
Published Article
Journal
Acta Pharmacologica Sinica
Publisher
Springer Nature
Publication Date
Feb 01, 2013
Volume
34
Issue
2
Pages
231–238
Identifiers
DOI: 10.1038/aps.2012.155
PMID: 23274414
Source
Medline
License
Unknown

Abstract

LPS stimulates NHE1 activity, increases [Ca(2+)](i), and activates calpain, which leads to endothelial cell apoptosis related to decreased Bcl-2 expression. Amiloride inhibits NHE1 activity, thus attenuates LPS-accelerated atherosclerosis in mice.

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