Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Amiloride attenuates lipopolysaccharide-accelerated atherosclerosis via inhibition of NHE1-dependent endothelial cell apoptosis.

Authors
  • 1
  • 1 Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun, China. , (China)
Type
Published Article
Journal
Acta Pharmacologica Sinica
1745-7254
Publisher
Nature Publishing Group
Publication Date
Volume
34
Issue
2
Pages
231–238
Identifiers
DOI: 10.1038/aps.2012.155
PMID: 23274414
Source
Medline
License
Unknown

Abstract

LPS stimulates NHE1 activity, increases [Ca(2+)](i), and activates calpain, which leads to endothelial cell apoptosis related to decreased Bcl-2 expression. Amiloride inhibits NHE1 activity, thus attenuates LPS-accelerated atherosclerosis in mice.

Statistics

Seen <100 times