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Amifostine in combination with erythropoietin and G-CSF promotes multilineage hematopoiesis in patients with myelodysplastic syndrome.

Authors
  • Neumeister, P
  • Jaeger, G
  • Eibl, M
  • Sormann, S
  • Zinke, W
  • Linkesch, W
Type
Published Article
Journal
Leukemia & lymphoma
Publication Date
Jan 01, 2001
Volume
40
Issue
3-4
Pages
345–349
Identifiers
PMID: 11426556
Source
Medline
License
Unknown

Abstract

Ineffective hematopoiesis leading to profound cytopenias represents a major clinical problem in the management of patients with myelodysplastic syndrome (MDS). The aminothiol amifostine has shown to promote multilineage hematopoiesis both in vivo and in vitro in patients with MDS. We have treated 10 patients with 250 mg/m2 amifostine thrice weekly in combination with erythropoietin for 4 consecutive weeks followed by 2 weeks observation. Responding patients received the same 6 week schedule, while nonresponder received G-CSF in addition to erythropoietin and amifostine during the second treatment course. All patients experienced single or multilineage hematologic improvement, but only 2 reached transfusion independency. Moreover, response was durable only in a minority of patients and thus additional studies are warranted to further define the potential interaction of amifostine and growth factors.

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