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Amelioration of cytotoxic-induced emesis with high-dose metoclopramide, dexamethasone and lorazepam.

Authors
  • Palmer, M C
  • Colls, B M
Type
Published Article
Journal
Cancer chemotherapy and pharmacology
Publication Date
Jan 01, 1987
Volume
19
Issue
4
Pages
331–334
Identifiers
PMID: 3297375
Source
Medline
Language
English
License
Unknown

Abstract

A double-blind randomised controlled trial comparing the antiemetic effects of sublingual lorazepam combined with high-dose, short course metoclopramide (3 mg/kg) infused twice 3 h apart with or without i.v. dexamethasone is reported. Sixty patients receiving a total of 209 cycles of potentially severely emetic cytotoxic chemotherapy were randomised to receive one or other antiemetic regimen. In those receiving platinum-based chemotherapy the addition of dexamethasone was associated with an improvement in freedom from nausea (P less than 0.01) and freedom from vomiting (P less than 0.05). In the non-platinum-based chemotherapy group the addition of dexamethasone led to a reduction in the duration and severity of nausea, and duration of vomiting (P less than 0.05 in each case). Both antiemetic regimens were well tolerated with a low incidence of adverse effects and could be administered easily in an outpatient setting.

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