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Amelanotic malignant melanoma of unknown primary origin metastasizing to the bone marrow: a case report and review of the literature.

Authors
  • Suzuki, Tomotaka
  • Kusumoto, Shigeru
  • Iida, Shinsuke
  • Tada, Toyohiro
  • Mori, Fumiko
Type
Published Article
Journal
Internal medicine (Tokyo, Japan)
Publication Date
Jan 01, 2014
Volume
53
Issue
4
Pages
325–328
Identifiers
PMID: 24531089
Source
Medline
License
Unknown

Abstract

We herein describe the case of a 77-year-old Japanese man who presented with progressive thrombocytopenia. No lymphadenopathies, bone lesions, hepatosplenomegaly or masses within any internal organs were detectable. Bone marrow smears revealed diffuse infiltration of large atypical cells morphologically resembling mature lymphoid neoplasms. A flow cytometric analysis showed that the tumor cells strongly expressed CD56 without myeloid or lymphoid antigens, suggesting that they were non-hematologic in origin. Ultimately, amelanotic malignant melanoma of unknown primary origin was diagnosed based on positive immunostaining for S100 proteins, HMB-45 and Melan-A. This case illustrates the usefulness of flow cytometric analyses for making such diagnoses. We also review the available literature on similar cases.

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