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Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta).

Authors
  • Gandy, Sam
  • DeMattos, Ron B
  • Lemere, Cynthia A
  • Heppner, Frank L
  • Leverone, Jodi
  • Aguzzi, Adriano
  • Ershler, William B
  • Dai, Jinlu
  • Fraser, Paul
  • Hyslop, Peter St George
  • Holtzman, David M
  • Walker, Lary C
  • Keller, Evan T
Type
Published Article
Journal
Alzheimer disease and associated disorders
Publication Date
Jan 01, 2004
Volume
18
Issue
1
Pages
44–46
Identifiers
PMID: 15195463
Source
Medline
License
Unknown

Abstract

Recent preliminary data suggest that vaccination with Alzheimer A beta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer disease. To examine the mechanisms and consequences of anti-A beta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated A beta 1-42. Immunized monkeys developed anti-A beta titers exceeding 1:1000, and their plasma A beta levels were 5- to 10-fold higher than the plasma A beta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer A beta.

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