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Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta).

Authors
Type
Published Article
Journal
Alzheimer disease and associated disorders
Publication Date
Volume
18
Issue
1
Pages
44–46
Identifiers
PMID: 15195463
Source
Medline
License
Unknown

Abstract

Recent preliminary data suggest that vaccination with Alzheimer A beta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer disease. To examine the mechanisms and consequences of anti-A beta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated A beta 1-42. Immunized monkeys developed anti-A beta titers exceeding 1:1000, and their plasma A beta levels were 5- to 10-fold higher than the plasma A beta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer A beta.

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