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Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins.

Authors
  • Young, R M
  • Mendoza, A E
  • Collins, T
  • Orkin, S H
Type
Published Article
Journal
Molecular and cellular biology
Publication Date
Nov 01, 1990
Volume
10
Issue
11
Pages
6051–6054
Identifiers
PMID: 2233732
Source
Medline
License
Unknown

Abstract

Two platelet-derived growth factor A-chain proteins, termed short and long A chains, are generated as a result of alternative mRNA splicing of exon 6 of the A-chain gene. S1 nuclease mapping and polymerase chain reaction analyses demonstrate that both short and long A-chain transcripts are expressed in a variety of normal tissues. In addition, immunohistochemical localization of long A-chain protein reveals a cellular distribution identical to that observed with platelet-derived growth factor heteroserum.

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