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Alternative splicing regulates the transcriptional activity of Drosophila heat shock transcription factor in response to heat/cold stress.

Authors
  • Fujikake, Nobuhiro
  • Nagai, Yoshitaka
  • Popiel, H Akiko
  • Kano, Hiroki
  • Yamaguchi, Masamitsu
  • Toda, Tatsushi
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jul 04, 2005
Volume
579
Issue
17
Pages
3842–3848
Identifiers
PMID: 15978579
Source
Medline
License
Unknown

Abstract

Heat shock transcription factor 1 (HSF1) mediates the induction of heat shock proteins in response to various types of stress. Although HSF1 activity is regulated by its post-translational modifications, alterations in mRNA expression have also been suggested. We here identified three new alternatively spliced isoforms of Drosophila HSF (dHSF) mRNA, named dHSFb, dHSFc, and dHSFd. We found that the ratio of dHSFb increases upon heat exposure, while that of dHSFd increases upon cold exposure. The dHSFc and dHSFd isoforms showed greater transcriptional activity than the other isoforms. Our findings suggest that alternative splicing regulates the transcriptional activity of dHSF.

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