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Alternative splicing: new insights from global analyses.

Authors
Type
Published Article
Journal
Cell
0092-8674
Publisher
Elsevier
Publication Date
Volume
126
Issue
1
Pages
37–47
Identifiers
PMID: 16839875
Source
Medline

Abstract

Recent analyses of sequence and microarray data have suggested that alternative splicing plays a major role in the generation of proteomic and functional diversity in metazoan organisms. Efforts are now being directed at establishing the full repertoire of functionally relevant transcript variants generated by alternative splicing, the specific roles of such variants in normal and disease physiology, and how alternative splicing is coordinated on a global level to achieve cell- and tissue-specific functions. Recent progress in these areas is summarized in this review.

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