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Altered Tissue Composition, Microarchitecture, and Mechanical Performance in Cancellous Bone From Men With Type 2 Diabetes Mellitus.

Authors
  • Hunt, Heather B1
  • Torres, Ashley M2
  • Palomino, Pablo M2
  • Marty, Eric3
  • Saiyed, Rehan3
  • Cohn, Matthew3
  • Jo, Jonathan3
  • Warner, Stephen3
  • Sroga, Grazyna E4
  • King, Karen B5, 6
  • Lane, Joseph M4
  • Vashishth, Deepak4
  • Hernandez, Christopher J2, 7, 8
  • Donnelly, Eve1, 8
  • 1 Department of Materials Science and Engineering, Cornell University, Ithaca, NY, USA.
  • 2 Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
  • 3 Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA.
  • 4 Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
  • 5 Department of Orthopedics, University of Colorado School of Medicine, Aurora, CO, USA.
  • 6 Surgical Service/Orthopaedic Service, Rocky Mountain Veterans Affairs Regional Medical Center, Aurora, CO, USA.
  • 7 Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA.
  • 8 Research Division, Hospital for Special Surgery, New York, NY, USA.
Type
Published Article
Journal
Journal of Bone and Mineral Research
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jul 01, 2019
Volume
34
Issue
7
Pages
1191–1206
Identifiers
DOI: 10.1002/jbmr.3711
PMID: 30866111
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

People with type 2 diabetes mellitus (T2DM) have normal-to-high BMDs, but, counterintuitively, have greater fracture risks than people without T2DM, even after accounting for potential confounders like BMI and falls. Therefore, T2DM may alter aspects of bone quality, including material properties or microarchitecture, that increase fragility independently of bone mass. Our objective was to elucidate the factors that influence fragility in T2DM by comparing the material properties, microarchitecture, and mechanical performance of cancellous bone in a clinical population of men with and without T2DM. Cancellous specimens from the femoral neck were collected during total hip arthroplasty (T2DM: n = 31, age = 65 ± 8 years, HbA1c = 7.1 ± 0.9%; non-DM: n = 34, age = 62 ± 9 years, HbA1c = 5.5 ± 0.4%). The T2DM specimens had greater concentrations of the advanced glycation endproduct pentosidine (+ 36%, P < 0.05) and sugars bound to the collagen matrix (+ 42%, P < 0.05) than the non-DM specimens. The T2DM specimens trended toward a greater bone volume fraction (BV/TV) (+ 24%, NS, P = 0.13) and had greater mineral content (+ 7%, P < 0.05) than the non-DM specimens. Regression modeling of the mechanical outcomes revealed competing effects of T2DM on bone mechanical behavior. The trend of higher BV/TV values and the greater mineral content observed in the T2DM specimens increased strength, whereas the greater values of pentosidine in the T2DM group decreased postyield strain and toughness. The long-term medical management and presence of osteoarthritis in these patients may influence these outcomes. Nevertheless, our data indicate a beneficial effect of T2DM on cancellous microarchitecture, but a deleterious effect of T2DM on the collagen matrix. These data suggest that high concentrations of advanced glycation endproducts can increase fragility by reducing the ability of bone to absorb energy before failure, especially for the subset of T2DM patients with low BV/TV. © 2019 American Society for Bone and Mineral Research. © 2019 American Society for Bone and Mineral Research.

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