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Altered SOCS3 DNA methylation within exon 2 is associated with increased mRNA expression in visceral adipose tissue in gestational diabetes.

Authors
  • Rancourt, Rebecca C1
  • Ott, Raffael1
  • Schellong, Karen1
  • Ziska, Thomas1
  • Melchior, Kerstin1
  • Henrich, Wolfgang2
  • Plagemann, Andreas1
  • 1 Division of 'Experimental Obstetrics', Clinic of Obstetrics, Charité- Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, Berlin Institute of Health, Berlin, Germany. , (Germany)
  • 2 Clinic of Obstetrics, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, Berlin Institute of Health, Berlin, Germany. , (Germany)
Type
Published Article
Journal
Epigenetics
Publisher
Landes Bioscience
Publication Date
May 01, 2021
Volume
16
Issue
5
Pages
488–494
Identifiers
DOI: 10.1080/15592294.2020.1805695
PMID: 32752921
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Overweight/obesity is the main risk factor for gestational diabetes mellitus (GDM). In our cohort of pregnant women with GDM, n = 19, and without, n = 22, we previously reported a significant increase in SOCS3 mRNA expression (+62%) in visceral adipose tissue (VAT) according to GDM, without altered promoter DNA-methylation. Here, we examined methylation status of additional SOCS3 exon 2 regions in VAT and maternal blood. We found significantly altered methylation at specific CpG sites corresponding to aberrant mRNA expression levels of SOCS3 in VAT. We propose a potential regulatory element/region within exon 2; however, this region does not appear to be a good blood-marker representing VAT.

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