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Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease

Authors
  • Siedlecki-Wullich, Dolores
  • Català-Solsona, Judit
  • Fábregas, Cristina
  • Hernández, Isabel
  • Clarimon, Jordi
  • Lleó, Alberto
  • Boada, Merce
  • Saura, Carlos A.
  • Rodríguez-Álvarez, José
  • Miñano-Molina, Alfredo J.
Type
Published Article
Journal
Alzheimer's Research & Therapy
Publisher
BioMed Central
Publication Date
May 15, 2019
Volume
11
Issue
1
Identifiers
DOI: 10.1186/s13195-019-0501-4
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundSeveral evidences suggest that failure of synaptic function occurs at preclinical stages of Alzheimer’s disease (AD) preceding neuronal loss and the classical AD pathological hallmarks. Nowadays, there is an urgent need to identify reliable biomarkers that could be obtained with non-invasive methods to improve AD diagnosis at early stages. Here, we have examined plasma levels of a group of miRNAs related to synaptic proteins in a cohort composed of cognitive healthy controls (HC), mild cognitive impairment (MCI) and AD subjects.MethodsPlasma and brain levels of miRNAs were analysed in two different cohorts including 38 HC, 26 MCI, 56 AD dementia patients and 27 frontotemporal dementia (FTD) patients. D’Agostino and Pearson and Shapiro-Wilk tests were used to evaluate data normality. miRNA levels between groups were compared using a two-sided nonparametric Mann-Whitney test and sensitivity and specificity was determined by receiver operating characteristic curve analysis.ResultsSignificant upregulation of miR-92a-3p, miR-181c-5p and miR-210-3p was found in the plasma of both MCI and AD subjects. MCI patients that progress to AD showed higher plasma levels of these miRNAs. By contrast, no changes in miR-92a-3p, miR-181c-5p or miR-210-3p levels were observed in plasma obtained from a cohort of FTD.ConclusionOur study shows that plasma miR-92a-3p, miR-181c-5p and miR-210-3p constitute a specific molecular signature potentially useful as a potential biomarker for AD.

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