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Altered microbiota composition reflects enhanced communication in 15q11-13 CNV mice.

Authors
  • Septyaningtrias, Dian Eurike1
  • Lin, Chia-Wen2
  • Ouchida, Rika2
  • Nakai, Nobuhiro2
  • Suda, Wataru3
  • Hattori, Masahira3
  • Morita, Hidetoshi4
  • Honda, Kenya5
  • Tamada, Kota2
  • Takumi, Toru6
  • 1 RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan; Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami, Hiroshima, 734-8553, Japan. , (Japan)
  • 2 RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan. , (Japan)
  • 3 RIKEN Center for Integrative Medical Sciences, Tsurumi, Yokohama, 230-0045, Japan. , (Japan)
  • 4 Graduate School of Environmental and Life Science, Okayama University, Kita, Okayama, 700-8530, Japan. , (Japan)
  • 5 RIKEN Center for Integrative Medical Sciences, Tsurumi, Yokohama, 230-0045, Japan; Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan. , (Japan)
  • 6 RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan; Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami, Hiroshima, 734-8553, Japan; RIKEN Center for Science and Technology Hub, Medical Sciences Innovation Hub Program (MIH), Japan; Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan. Electronic address: [email protected] , (Japan)
Type
Published Article
Journal
Neuroscience research
Publication Date
Dec 01, 2020
Volume
161
Pages
59–67
Identifiers
DOI: 10.1016/j.neures.2019.12.010
PMID: 31863791
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder. In addition to the core symptoms of ASD, many patients with ASD also show comorbid gut dysbiosis, which may lead to various gastrointestinal (GI) problems. Intriguingly, there is evidence that gut microbiota communicate with the central nervous system to modulate behavioral output through the gut-brain axis. To investigate how the microbiota composition is changed in ASD and to identify which microbes are involved in autistic behaviors, we performed a 16S rRNA gene-based metagenomics analysis in an ASD mouse model. Here, we focused on a model with human 15q11-13 duplication (15q dup), the most frequent chromosomal aberration or copy number variation found in ASD. Species diversity of the microbiome was significantly decreased in 15q dup mice. A combination of antibiotics treatment and behavioral analysis showed that neomycin improved social communication in 15q dup mice. Furthermore, comparison of the microbiota composition of mice treated with different antibiotics enabled us to identify beneficial operational taxonomic units (OTUs) for ultrasonic vocalization. Copyright © 2019 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.

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