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Altered mandibular development precedes the time of palate closure in mice homozygous for disproportionate micromelia: an oral clefting model supporting the Pierre-Robin sequence.

Authors
  • Ricks, James E
  • Ryder, Victoria M
  • Bridgewater, Laura C
  • Schaalje, Bruce
  • Seegmiller, Robert E
Type
Published Article
Journal
Teratology
Publication Date
Mar 01, 2002
Volume
65
Issue
3
Pages
116–120
Identifiers
PMID: 11877774
Source
Medline
License
Unknown

Abstract

Mandibular growth retardation, coupled with relative macroglossia in E14 Dmm/Dmm mice, suggests that the concerted development of the palate and lower jaw complex in the mutant is aberrant. Detection of micrognathia and pseudomacroglossia in homozygotes, before the time of palate closure, supports the hypothesis that a relationship exists between growth retardation of Meckel's cartilage and malformation of the secondary palate, as predicted by the Pierre-Robin sequence.

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