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Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue.

Authors
  • Kubota, Takehiko
  • Itagaki, Manami
  • Hoshino, Chika
  • Nagata, Masaki
  • Morozumi, Toshiya
  • Kobayashi, Tetsuo
  • Takagi, Ritsuo
  • Yoshie, Hiromasa
Type
Published Article
Journal
Journal of periodontology
Publication Date
Jan 01, 2008
Volume
79
Issue
1
Pages
166–173
Identifiers
DOI: 10.1902/jop.2008.070159
PMID: 18166107
Source
Medline
License
Unknown

Abstract

Upregulated MMP expression and an increased MMP/TIMP ratio indicate that a potential imbalance between degradation and synthesis of extracellular matrix persists in periodontitis-affected gingival tissues. This process may be responsible for increased tissue breakdown in periodontitis.

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