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Alterations in the number of glucocorticoid receptors of circulating lymphocytes in sepsis.

Authors
Type
Published Article
Journal
Haematologia
Publication Date
Volume
19
Issue
4
Pages
293–298
Identifiers
PMID: 3817609
Source
Medline
License
Unknown

Abstract

A 2-to 16-fold increase in the number of glucocorticoid receptors of circulating lymphocytes was observed in 17 septic patients as compared to 10 control patients with no inflammatory disease. The number of receptors was low in 3 septic patients who did not respond to antibiotic and glucocorticoid therapy and died. Intravenous administration of 100 mg of cortisol reduced the number of receptors available to the assay by about 30% in both septic and control patients.

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