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Alterations of insulin sensitivity by the implantation of 3T3-L1 cells in nude mice. A role for TNF-alpha?

Authors
  • Shibasaki, M
  • Takahashi, K
  • Itou, T
  • Miyazawa, S
  • Ito, M
  • Kobayashi, J
  • Bujo, H
  • Saito, Y
Type
Published Article
Journal
Diabetologia
Publication Date
Apr 01, 2002
Volume
45
Issue
4
Pages
518–526
Identifiers
PMID: 12032627
Source
Medline
License
Unknown

Abstract

This method of implanting adipose cells into subcutaneous or visceral fat area showed high TNF-alpha concentration and insulin resistance by the adipose cells in visceral area of nude mice. Furthermore, we found that the functional significance of visceral fat accumulation for TNF-alpha-induced insulin resistance is partly caused by the interaction of adipocytes with surrounding conditions in mesenteric area.

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